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Sean Clapshaw

Director

Biography

Sean is Solomon Park’s director. He is responsible for managing day to day operations, improving internal processes, and meeting the expectations and needs of our clients.

Sean got his introduction to laboratory life when his father moved the family to Germany to take up a position at Max Planck. He spent five years in Germany, became fluent in German. And he went to the laboratory after school, where he would watch his Dad and researchers work with centrifuges and spectrophotometers. There was one caveat, however; don’t push any buttons!

Back in the USA, when Sean was in high school, and Dr. Clapshaw started Solomon Park, Sean worked in the laboratory as an assistant and did everything from implementing technology to isolating lipoproteins. He joined the company full-time in 2008 and has never looked back.

Honors

Observer – Subcommittee on Validating and Implementing Secondary Reference Materials (Clinical and Laboratory Standards Institute)
Observer – National Reference System for the Clinical Laboratory Council
Treasurer – Lipids and Lipoprotein Division (AACC) 1999-2000
Member at Large – Lipids and Lipoprotein Division Management Team (AACC) 1998-
Acting Director – Neurobiology Section Friederich-Meischer Laboratory, the Max Planck Institute, Tuebingen, West Germany, Nov-Jan., 1976-1980

Peer Reviewed Publications

Clapshaw, P. and Schelsinger, K. In Vitro Incorporation of uridine triphosphate into nuclei of trained and control mice in Neuroscience Abstracts of the Sixth Annual Meeting of the Society of Neuroscience. Vol. II, p. 427 (1976).

Clapshaw, P. and Seifert, W. Isolation and characterization of 2′:3′-cyclic-nucleotide 3′-phosphodiesterase from bovine cerebral white matter. Hoppe-Seyler’s Zeitschrift fur Physic u. Chemistry. 358., p. 1189-90. (1977)

Clapshaw, P. and Seifert, W. Effects of detergents, proteins and lipids on 2: ‘3’-cyclic-nucleotide 3′-phosphodiesterase activity. J. Neurochem. 35, p. 164-69. (1980)

Clapshaw, P.A., Mueller, H.W. and Seifert, W. Characterization of 2′: 3′-cyclic-nucleotide 3′-phosphodiesterase: rapid isolation, native enzyme analysis, identification of a serum-soluble activity and kinetics. J. Neurochem. 36, p. 1996-2003. (1980)

Mueller, H.W., Clapshaw, P.A. and Seifert, W. Evidence for intracellular localization of 2′:3′-cyclic-nucleotide 3′-phosphosiesterade: limited proteolytic digestion, plant lectin affinity chromatography and immunological identification. J. Neurochem. 36, p. 2004-12 (1980)

Ranscht, B., Clapshaw, P.A., Price, J., Noble, M. and Seifert, W. A. monoclonal antibody used to follow the developmental appearance of surface galactosphingolipids in oligodendrocytes and Schwann Cells. Proc. Natl. Acad. Sci. U.S.A. 79, p. 2709-13. (1980).

Mueller, H.W., Clapshaw, P.A. and Seifert, W. Evidence for intracellular localization of 2′:3′-cyslic-cucleotide 3′-phosphodiesterase as examined by immunofluorescence and cell fractionation. J. Neurochem. 37, p. 947-55. (1981)

Ranscht, B., Clapshaw, P.A. and Seifert, W. Two molecular forms of the isolated brain enzyme 2′:3’-cyclic-nucleotide 3′-phosphodiesterase. FEBS Letters. 131, 37-40. (1981)

Clapshaw, P.A., Mueller, H.W., Weitholter, K. M. and Seifert, W. Simultaneous measurement of RNase and 2′:3′-cyclicnucleotide 3′-phosphodiesterase activities in the sera and spinal fluids of multiple sclerosis and control patients. J. Neurochem. 42, 12-15 (1984)

Warnick GR and Clapshaw PA, Avalibility of plasma with target values for certain lipids. Clin Chem. Dec; ;33(12):2323-4( 1987).

Mandell, H., Steene A.C., Reinhardt, B.N., Yoshinari, N., Weiner H.L., Clapshaw, P.A., and Munsal, T.L, Lack of antibodies to Borrelia burgdorferi in patients with Amyotrophic lateral sclerosis. New England Journal of Medicine. (1989)

Stratton, M.D. Perna V.P. and Clapshaw, P.A. Zero-Bias Cholesterol and Triglyceride Proficiency Survey. Clin Chem 368, 1855- 1856 (1990)

Lathia, K.B., Yan, Z., and Clapshaw, P.A. Spinal cord transcriptome analysis using suppression subtractive hybridization and mirror orientation selection. Cell Mol Neurobiol. 2006 May; 26(3):259-75. Epub 2006 Apr 18.(2006)

Yan Z. Lathia KB, and Clapshaw, PA Murine Spinal Cord Transcriptome Analysis Following Reduction of Prevalent Myelin cDNA Sequences. Cell Mol Neurobiol Feb 14 [Epub ahead of print] (2008)

Lathia, KB, Yan Z. and Clapshaw, PA Strategy for verifying myelin sequence up regulation in spinal cord transcriptomes( in progress).