PBMCs (Peripheral Blood Mononuclear Cells)
PBMCs (Peripheral Blood Mononuclear Cells)Peripheral Blood Mononuclear Cells isolated from human whole blood samples are effective tools for the in vitro evaluation of various elements of pathology and biology. For example, they can be used to measure the human body’s inflammatory response to biomedical devices implanted into the body. They are also a useful tool when determining the body’s natural immunity to viruses, bacteria, and parasites.
What are PBMCs?
A Peripheral Blood Mononuclear Cell (PBMC) is a peripheral blood cell with a round nucleus or center. These cells consist of lymphocytes (T cells, B cells, NK cells), and monocytes. As an aside, erythrocytes, granulocytes, and platelets do not have a round nucleus so they do not form part of the PBMC grouping. Lymphocytes are the greatest PBMC subsector, followed by monocytes.
At our Solomon Park Research Laboratory, PBMCs are extracted from whole blood using a centrifuge and ficoll, a hydrophilic polysaccharide that separates the human blood sample into three layers: a top layer of plasma, then the layer of PBMCs, and the polymorphonuclear cells at the bottom.
We have a wide database of donors who are able and willing to donate blood to various research projects. Contact Solomon Park Research Laboratories should you wish to enquire about our PBMC samples for your research study.
In Vitro Research Studies
Recent studies show that PBMCs could be sensitive to pathogenic infections such as parasitic and bacterial infections, triggering their immune function as they attempt to rid the body of the bacteria or parasites. PBMCs may also be susceptible to viral infections, providing scientists and researchers with the option to study PBMCs and their relationship to the SARS-CoV-2 virus.
High numbers of PBMCs in human blood samples are often an indicator of disease. In the COVID-19 context, it could mean that the individual who donated the blood has been exposed to the SARS-CoV-2 virus and either still has the viral load in their bloodstream, or they have recovered from the effects of the illness.
The efficacy of immunosuppressant drugs can be measured by isolating the number of PBMCs in human blood.
PBMCs are also valuable tools for research studies that look at the drug toxicity analysis during the development of new drugs. The PBMCs present in the human blood sample demonstrates the toxicity potential of the new medicinal aggregates on the human immune system.
Another important aspect to measure is the effects of drug toxicity on PBMCs. They have the potential to result in serious toxic effects, including the suppression and toxicity of the human immune system.
Contact Solomon Park Research Labs
Solomon Park prides itself on the quality of our PBMC samples that we make available for researchers to conduct in vitro studies using PBMCs as a basis for a study.
Schedule a consultation with Solomon Park Research Laboratories to discuss your PBMC sample requirements. Our consultants are waiting to talk with you.