Patric Clapshaw
Founder & Scientific Director
Biography
Dr. Patric Clapshaw is Solomon Park Research Laboratories’ Scientific Director. He manages our blood draw center and oversees a manufacturing center for proficiency testing, calibrator, and control materials. These materials are used both domestically and internationally to set instrumentation and perform research.
He has a very strong background in research, clinical chemistry, and neurochemistry. As part of his Ph.D. studies, Dr. Clapshaw has worked in Germany as a research scientist and acting director at the Max Planck Institute.
He has conducted extensive research into the following areas, including:
- Enzymology, protein isolation, immunology (monoclonal antibodies)
- Neurobiology (general and neurological diseases)
- Neuromuscular Disease (Suppression Subtractive Hybridization)
Finally, he has co-authored over 10 medical journal articles in these areas, including an article titled, “The availability of plasma with target values for certain lipids.”
Education & Training
B. A. Zoology | University of Washington, 1967
Secondary Teaching Credential | University of California, Los Angeles, 1968
M.A. Exp. Psychology | San Francisco State College, 1972
PhD Neurochemistry | University of Colorado, Boulder, 1976
Professional Memberships
American Association of Clinical Chemists
International Society of Neurochemistry
American Society of Neurochemistry
Positions and Employment
1965 — 1966 — Research Technician in Human Genetics, University of Washington,
Seattle and City of Hope, Duarte
1968 — 1969: High School Science Teacher, Bayshore School District, Daly City
1969 — 1970: Technical Assistant in Medical Technology, San Francisco State College, San Francisco
1970 — 1971: Research Technician in Cancer Research, University of California Medical Center San Francisco
1972 — Teaching Assistant in Statistics, University of Colorado, Boulder
1972 — 1973: Instructor in General Psychology, University of Colorado, Boulder
1974 — Instructor in Physiological Psychology, University of Colorado, Boulder
1972 — 1974: Teaching Assistant in Molecular, Cellular and Developmental Biology, University of Colorado, Boulder
1975 — Research Assistant in Behavioral Genetics, Univ. of Colorado, Boulder
1974 — 1976: Instructor in Molecular, Cellular and Developmental Biology, University of Colorado, Boulder
1976 — 1981: Acting Director and Principle Investigator in Neurochemistry Max Planck Institute
1981 — 1983: Senior Staff Scientist in Neurobiology, the Queen’s Medical Center in Honolulu, HI
1983 — 1985: Principal Investigator in Neurobiology, Issaquah Health Institute
1985 — 1986: Research Scientist/Apolipoprotein Antibody Standardization Project, NWLRL
1986: Director of Research/Proficiency Testing Program, Solomon Park Research Institute; Director, Solomon Park Research Laboratories
Work Experience & Skills
Research
• Enzymology, protein isolation, immunology (monoclonal antibodies)
• Neurobiology (general and neurological diseases)
• Neuromuscular Disease (Suppression Subtractive Hybridization)
Languages Spoken
• English (native)
• German (second)
Teaching
• Biology, (Molecular, Cellular and Developmental)
• Psychology, (General and Physiological)
• Mathematics (General and Statistics)
Military Service
Vietnam-era Veteran,
Honorably Discharged from the US Army
Honors
Observer – Subcommittee on Validating and Implementing Secondary Reference Materials (Clinical and Laboratory Standards Institute)
Observer – National Reference System for the Clinical Laboratory Council
Treasurer – Lipids and Lipoprotein Division (AACC) 1999-2000
Member at Large – Lipids and Lipoprotein Division Management Team (AACC) 1998-
Acting Director – Neurobiology Section Friederich-Meischer Laboratory, the Max Planck Institute, Tuebingen, West Germany, Nov-Jan., 1976-1980
Peer Reviewed Publications
Clapshaw, P. and Schelsinger, K. In Vitro Incorporation of uridine triphosphate into nuclei of trained and control mice in Neuroscience Abstracts of the Sixth Annual Meeting of the Society of Neuroscience. Vol. II, p. 427 (1976).
Clapshaw, P. and Seifert, W. Isolation and characterization of 2′:3′-cyclic-nucleotide 3′-phosphodiesterase from bovine cerebral white matter. Hoppe-Seyler’s Zeitschrift fur Physic u. Chemistry. 358., p. 1189-90. (1977)
Clapshaw, P. and Seifert, W. Effects of detergents, proteins and lipids on 2: ‘3’-cyclic-nucleotide 3′-phosphodiesterase activity. J. Neurochem. 35, p. 164-69. (1980)
Clapshaw, P.A., Mueller, H.W. and Seifert, W. Characterization of 2′: 3′-cyclic-nucleotide 3′-phosphodiesterase: rapid isolation, native enzyme analysis, identification of a serum-soluble activity and kinetics. J. Neurochem. 36, p. 1996-2003. (1980)
Mueller, H.W., Clapshaw, P.A. and Seifert, W. Evidence for intracellular localization of 2′:3′-cyclic-nucleotide 3′-phosphosiesterade: limited proteolytic digestion, plant lectin affinity chromatography and immunological identification. J. Neurochem. 36, p. 2004-12 (1980)
Ranscht, B., Clapshaw, P.A., Price, J., Noble, M. and Seifert, W. A. monoclonal antibody used to follow the developmental appearance of surface galactosphingolipids in oligodendrocytes and Schwann Cells. Proc. Natl. Acad. Sci. U.S.A. 79, p. 2709-13. (1980).
Mueller, H.W., Clapshaw, P.A. and Seifert, W. Evidence for intracellular localization of 2′:3′-cyslic-cucleotide 3′-phosphodiesterase as examined by immunofluorescence and cell fractionation. J. Neurochem. 37, p. 947-55. (1981)
Ranscht, B., Clapshaw, P.A. and Seifert, W. Two molecular forms of the isolated brain enzyme 2′:3’-cyclic-nucleotide 3′-phosphodiesterase. FEBS Letters. 131, 37-40. (1981)
Clapshaw, P.A., Mueller, H.W., Weitholter, K. M. and Seifert, W. Simultaneous measurement of RNase and 2′:3′-cyclicnucleotide 3′-phosphodiesterase activities in the sera and spinal fluids of multiple sclerosis and control patients. J. Neurochem. 42, 12-15 (1984)
Warnick GR and Clapshaw PA, Avalibility of plasma with target values for certain lipids. Clin Chem. Dec; ;33(12):2323-4( 1987).
Mandell, H., Steene A.C., Reinhardt, B.N., Yoshinari, N., Weiner H.L., Clapshaw, P.A., and Munsal, T.L, Lack of antibodies to Borrelia burgdorferi in patients with Amyotrophic lateral sclerosis. New England Journal of Medicine. (1989)
Stratton, M.D. Perna V.P. and Clapshaw, P.A. Zero-Bias Cholesterol and Triglyceride Proficiency Survey. Clin Chem 368, 1855- 1856 (1990)
Lathia, K.B., Yan, Z., and Clapshaw, P.A. Spinal cord transcriptome analysis using suppression subtractive hybridization and mirror orientation selection. Cell Mol Neurobiol. 2006 May; 26(3):259-75. Epub 2006 Apr 18.(2006)
Yan Z. Lathia KB, and Clapshaw, PA Murine Spinal Cord Transcriptome Analysis Following Reduction of Prevalent Myelin cDNA Sequences. Cell Mol Neurobiol Feb 14 [Epub ahead of print] (2008)
Lathia, KB, Yan Z. and Clapshaw, PA Strategy for verifying myelin sequence up regulation in spinal cord transcriptomes( in progress).